Direct incorporation of hydroxyproline into protein of sycamore cells incubated at growth-inhibitory levels of hydroxyproline.
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چکیده
منابع مشابه
Direct incorporation of hydroxyproline into protein of sycamore cells incubated at growth-inhibitory levels of hydroxyproline.
Free hydroxyproline inhibits the growth of animals1' I and plants.3-7 The mechanism of this inhibition is not known. Among the theoretically possible effects of hydroxyproline are: (1) reduction of protein synthesis by lowering proline incorporation, (2) interference with proline hydroxylation, and (3) direct incorporation of hydroxyproline resulting in nonfunctional proteins. Hydroxyproline re...
متن کاملConversion of proline to hydroxyproline and its incorporation into collagen.
Most, if not all, of the hydroxyproline in collagen appears to be derived from proline (1, 2). It has been proposed by several investigators (2-7), on indirect evidence, that it is a bound form of proline which is hydroxylated and incorporated into collagen. Recent data (8-11) indicate an analogous situation in the hydroxylation of lysine and its incorporation into collagen. The type of compoun...
متن کاملIncorporation of cis-hydroxyproline into protocollagen and collagen. Collagen containing cis-hydroxyproline in place of proline and trans-hydroxyproline is not extruded at a normal rate.
Incubation of cartilage from chick embryos with l*C3,5-cis-hydroxy-DL-proline demonstrated that cis-hydroxyproline is incorporated into the collagen and other protein synthesized by the tissue. Gel filtration of extracts from the tissue demonstrated that the proteins synthesized in the presence of cis-hydroxyproline were about the same size as proteins synthesized under control conditions. Incu...
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Contiguous hydroxyproline residues direct hydroxyproline arabinosylation in Nicotiana tabacum.
Hydroxyproline (Hyp) O-glycosylation characterizes the hydroxyproline-rich glycoprotein (HRGP) superfamily of the plant extracellular matrix. Hyp glycosylation occurs in two modes: Arabinosylation adds short oligoarabinosides (Hyp-arabinosides) while galactosylation leads to the addition of larger arabinogalactan polysaccharides (Hyp-polysaccharides). We hypothesize that sequence-dependent glyc...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1967
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.57.1.50